bs-83041C
[Life Science]
WP1066
DATASHEET
Formulation White solid
Storage: -20°C
Product Information:
WP1066 (857064-38-1) is an inhibitor of the JAK2/STAT3 pathway as well as STAT5 and AKT.1,2,3 It downregulated Bcl-XL, Mcl-1, and c-myc while activating Bax and inducing apoptosis.1 Active against human malignant glioma U87-MG (IC50 = 5.6µM) and U373-MG (IC50 = 3.7µM) cells. Enhances T-cell cytotoxicity via inhibition of regulatory T-cells.4,5 WP1066 abrogated PD-L1 expression in lymphoma cell lines.6
Description:
CAS Number: 857064-38-1<br></br>Chemical Name: (E)-3-(6-Pyridin-2-yl)-2-cyano-N-[(1S)-1-phenylethyl]prop-2-enamide<br></br>Molecular weight: 356.22<br></br>Formula: C18H14BrN3O<br></br>Solubility: DMSO (>25 mg/ml)<br></br>Physical Properties: White solid<br></br>Purity: 98% by HPLC NMR (Conforms)
Size: 10 mg, 50 mg10 mg, 50 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.