bs-83038C

DATASHEET

Formulation Off-white solid

Storage: -20°C

Product Information:

IPI-549 is a potent and highly selective inhibitor of PI3K- in both biochemical (IC50 = 16 nM) and cellular (IC50 = 12.2 nM) assays.1 Macrophage PI3K- has been found to be a critical switch between immune stimulation and suppression.2 IPI-549 has been used to reshape tumor immune microenvironments and promote cytotoxic T-cell-mediated tumor regression. Resistance to immune checkpoint blockade in 4T1 and B16-GMCSF tumors was overcome when anti-PD-1 or anti-CTLA4 therapies were combined with PI3K inhibition via IPI-549.3 IPI-549 mono-treatment also resulted in tumor growth inhibition in several cancer cell lines.3 IPI-549 has also been shown to modulate P-glycoprotein-mediated multidrug resistance.4

Description:

CAS Number: 1693758-51-8 Chemical Name: (S)-2-Amino-N-[1-[8-[2-(1-methylpyrazol-4-yl)ethynyl]-1-oxo-2-phenylisoquinolin-3-yl]ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide Molecular weight: 629.68 Formula: C30H24N8O2 Solubility: DMSO (>25 mg/ml) Physical Properties: Pale yellow solid Purity: >98% by HPLC NMR (conforms)