bs-83034C
[Life Science]
Volasertib
DATASHEET
Formulation White solid
Storage: -20°C
Product Information:
Volasertib is an extremely potent and selective inhibitor (IC50’s: Plk1= 0.87 nM, Plk2 = 5 nM, Plk3 = 56 nM) of Polo-like kinase 1, a critical controller of multiple essential steps of mitosis.1 It has shown efficacy in multiple solid xenograft tumors models1 and in clinical studies in patients with acute myeloid leukemia2. Volasertib has also been shown to potently inhibit BRD43 (Kd = 79 nM3, IC50’s bromodomains 1 and 2 of BRD4 = 300 and 770 nM respectively2).
Description:
CAS Number: 755038-65-4<br></br>Chemical Name: N-[4-[4-(Cyclopropylmethyl)piperazin-1-yl]cyclohexyl]-4-[[(7R)-7-ethyl-5-methyl-6-oxo-8-propan-2-yl-7H-pteridin-2-yl]amino]-3-methoxybenzamide<br></br>Molecular weight: 618.82<br></br>Formula: C34H50N8O3 <br></br>Solubility: DMSO (>25 mg/ml)<br></br>Physical Properties: Off-white solid<br></br>Purity: 98% by HPLC NMR (Conforms)
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.