bs-83030C
[Life Science]
Quizartinib
DATASHEET
Formulation Off-white to beige solid
Storage: -20°C
Product Information:
Quizartinib is a potent and selective inhibitor of FLT3 (Kd = 1.6nM, IC50 = 0.56 nM MV4-11 cells).1 It is in clinical trials for treatment of Acute Myelogenous Leukemia (AML).2,3 Quizartinib priming resulted in prevention of myelosuppression in mice treated with 5-FU and Gemcitabine.4 Quizartinib showed significant reversal of ABCG2-mediated multidrug resistance (@ 3 µM) via antagonism of drug efflux function.5,6
Description:
CAS Number: 950769-58-1<br></br>Chemical Name: 1-(5-(t-Butyl)isoxazol-3-yl)-3-(4-(7-(2-morpholinoethoxy)benzo[d]imidazo[2,1-b]thiazol-2-yl)phenyl)urea<br></br>Molecular weight: 560.67<br></br>Formula: C29H32N6O4S<br></br>Solubility: DMSO (>25 mg/ml)<br></br>Physical Properties: Off-whtie solid<br></br>Purity: 98% by HPLC
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.