bs-83017C
[Life Science]
Crenolanib
DATASHEET
Formulation Pale yellow solid
Storage: -20°C
Product Information:
Crenolanib is a potent inhibitor of PDGFR (Kd for α = 2.1 nM; ß = 3.2 nM) and FLT3 (Kd = 0.74 nM).1 Crenolanib is a type I inhibitor binding only to the active kinase conformation. It showed potent activity against imatinib-resistant PDGFRα mutations D842I, D842V, D842Y, DI842-843M, and deletion I8432 as well as FLT3/ITD and FLT3/D835 mutants3. Crenolanib acted synergistically with FLT3-CAR T-cells in a FLT3-ITD+ AML murine xenograft model.4
Description:
CAS Number: 670220-88-9<br></br>Chemical Name: 1-[2-[5-[(3-Methyloxetan-3-yl)methoxy]benzimidazole-1-yl]quinoline-8-yl]piperidin-4-amine<br></br>Molecular weight: 443.55<br></br>Formula: C26H29N5O2 <br></br>Solubility: DMSO (15 mg/ml) Ethanol (10 mg/ml)<br></br>Physical Properties: White solid<br></br>Purity: 97% by HPLC NMR (Conforms)
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.