bs-83016C
[Life Science]
JNK-IN-8
DATASHEET
Formulation Off-white solid
Storage: -20°C
Product Information:
JNK-IN-8 is a potent and selective irreversible JNK inhibitor (IC50s=4.67, 18.7 and 0.98 nM for JNK1, 2 and 3 respectively).1 JNK blockade with JNK-IN-8 overcomes PD-L1-mediated resistance to chemotherapy in colorectal cancer.2 Improves ARDS-induced cognitive impairment by inhibition of JNK/NF-kB-mediated NLRP3 inflammasome activation.3
Description:
CAS Number: 1410880-22-6<br></br>Chemical Name: 3-[[4-(Dimethylamino)-1-oxo-2-buten-1-yl]amino]-N-[3-methyl-4-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide<br></br>Molecular weight: 507.6<br></br>Formula: C29H29N7O2<br></br>Solubility: DMSO (45 mg/ml)<br></br>Physical Properties: Pale yellow solid<br></br>Purity: >98% by HPLC NMR (Conforms)
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.