bs-83014C
[Life Science]
AZ3146
DATASHEET
Formulation Yellow/brown solid
Storage: -20°C
Product Information:
AZ3146 is a potent (IC50 = 35 nM) and selective monopolar spindle 1 (Mps1/TTK) kinase inhibitor.1 Mps1 has an essential role in the spindle assembly checkpoint, an inhibitory network that restrains anaphase until all kinetochores are stably attached to spindle microtubules during mitosis. AZ3146 decreased hepatocellular carcinoma growth in vitro (SMMC-7721 and BEL-7404 cells).2
Description:
CAS Number: 1124329-14-1<br></br>Chemical Name: 9-Cyclopentyl-2-[2-methoxy-4-(1-methylpiperidine-4-yl)oxyanilino]-7-methylpurin-8-one<br></br>Molecular weight: 452.56<br></br>Formula: C24H32N6O3S2 <br></br>Solubility: DMSO (10 mg/ml) Eathnaol (>25 mg/ml)<br></br>Physical Properties: Off-white solid<br></br>Purity: 98% by HPLC NMR (conforms)
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.