bs-83012C
[Life Science]
MOMIPP
DATASHEET
Formulation Yellow solid
Storage: -20°C
Product Information:
MOMIPP is an inducer of Methuosis, a novel form of nonapoptotic cell death.1 Methuosis is characterized by fusion of macropinocytotic vesiscles into progressively larger vacuoles resulting in a decrease in metabolic activity and rupture of the cell membrane.2 MOMIPP was able to effectively reduce the growth and viability of Temozolomide-resistant glioblastoma and doxorubicin-resistant breast cancer cells at low micromolar concentrations. MOMMIP has also been shown to disrupt vesicular trafficking at the lysosomal nexus resulting in impaired degradation of EGF and LDL receptors, defective processing of procathepsins and accumulation of autophagosomes.3
Description:
CAS Number: 1363421-46-8<br></br>Chemical Name: trans-3-(5-Methoxy-2-methyl-1H-indol-3-yl)-1-(4-pyridinyl)-2-propen-1-one<br></br>Molecular weight: 292.33<br></br>Formula: C18H16N2O2 <br></br>Solubility: DMSO (7 mg/ml)<br></br>Physical Properties: Orange solid<br></br>Purity: 98% by TLC NMR (Conforms)
Size: 10 mg, 50 mg10 mg, 50 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.