bs-83010C
[Life Science]
LDN-193189 HCl
DATASHEET
Formulation White solid
Storage: -20°C
Product Information:
LDN-193189 HCl is a potent and selective inhibitor of ALK2 (IC50 = 5 nM) and ALK3 (IC50 = 30 nM), thereby inhibiting SMAD1/5/8 phosphorylation.1 Only weak inhibition of ALK4, ALK5, and ALK7 is observed. Promotes neuronal differentiation of human pluripotent stem cells.2-3 LDN-193189 HCl has also been used to examine the role of osteogenesis in prostate tumor metastases in bone.4
Description:
CAS Number: 1062368-62-0<br></br>Chemical Name: 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline hydrochloride<br></br>Molecular weight: 479.4<br></br>Formula: C25H22N6·2HCl<br></br>Solubility: DMSO or Water (up to 5 mg/ml)<br></br>Physical Properties: Orange-yellow solid<br></br>Purity: 99% by HPLC (Agilent Poroshell 120 C18, 80/20 MeOH/water with 0.05% TFA; 0.8 ml/min) NMR (Conforms)
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.