bs-83008C
[Life Science]
GSK583
DATASHEET
Formulation White solid
Storage: -20°C
Product Information:
GSK583 is a highly selective and potent inhibitor of RIP2 kinase, IC50 = 5 nM human and IC50 = 2 nM rat.1 It also potently Inhibits isolated RPI3 kinase (IC50 = 5 nM) but is inactive against RIP3 in cellular assays due to a very low KM,ATP. GSK583 blocks NOD2 signaling by interfering with XIAP-RIP2 binding resulting in decreased cytokine and chemokine production.1,2
Description:
CAS Number: 1346547-00-9<br></br>Chemical Name: 6-tert-Butylsulfonyl-N-(5-fluoro-1H-indazol-3-yl)quinoline-4-amine<br></br>Molecular weight: 398.45<br></br>Formula: C20H19FN4O2S<br></br>Solubility: DMSO (>25 mg/ml)<br></br>Physical Properties: Pale yellow solid<br></br>Purity: 98% by HPLC NMR (Conforms)
Size: 50mg,10mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.