bs-82992C
[Life Science]
GSK8612
DATASHEET
Formulation Off-white solid
Storage: -20°C
Product Information:
Highly selective and potent (avg. pIC50 = 6.8 versus recombinant TBK1) inhibitor of Tank-binding Kinase-1 (TBK1) with higher affinity for unactivated TBK1. It inhibited phosphorylation of IRF3 (pIC50 = 6.0), inhibited the release of IFNa from human PBMC’s (pIC50 = 6.1), and inhibited IFNb secretion from THP-1 cells (pIC50 = 5.8 dsDNA virus, 6.3 cGAMP stilmulated cells).
Description:
CAS Number: 2361659-62-1<br></br>Chemical Name: 4-[[[5-Bromo-2-[[3-methyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]amino]pyrimidin-4-yl]amino]methyl]benzenesulfonamide<br></br>Molecular weight: 520.33<br></br>Formula: C17H17BrF3N7O2S<br></br>Solubility: Soluble in DMSO (20 mg/ml)<br></br>Physical Properties: Beige solid<br></br>Purity: 98% by HPLC NMR (Conforms)
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.