DATASHEET
Formulation
White solid
Storage:
-20°C
Product Information:
Activator of NRF2 signaling (EC50 ~ 1 µM cellular ARE-LUC assay).1 It inhibits phosphoglycerate kinase 1 leading to a build-up of methylglyoxal which inactivates KEAP1. It protected SH-SY5Y neuronal cells from MPP+ induced oxidative injury via activation of NRF2 signaling.2
Description:
CAS Number: 2416095-06-0<br></br>Chemical Name: trans-4-(4-Chlorophenyl)sulfonyl-N-(2-methylpropyl)-1,1-dioxothiolan-3-amine<br></br>Molecular weight: 365.89<br></br>Formula: C14H20ClNO4S2<br></br>Solubility: DMSO (>25 mg/ml)<br></br>Physical Properties: White solid<br></br>Purity: 98% by HPLC NMR (Conforms)