bs-82976C
[Life Science]
PB28 dihydrochloride
DATASHEET
Formulation White solid
Storage: -20°C
Product Information:
PB28 is a very potent high affinity (Ki = 5.3 nM1, 0.34 nM2) sigma 2 agonist. Selective for sigma 2 over sigma1 (approx 30-40x).1,2 PB28 inhibited cell growth in MCF7 and MCF7 ADR breast cancer cells and displayed strong synergism with doxorubicin.3 PB28 potently inhibited Kv2.1 currents in a sigma-independent manner.4 PB28 was recently found to have potent (IC50 = 280 nM) anti-SARS-CoV2 activity.5
Description:
CAS Number: 172907-03-8<br></br>Chemical Name: 1-Cyclohexyl-4-[3-(1,2,3,4-tetrahydro-5-methoxy-1-naphthalenyl)propyl]piperazine dihydrochloride<br></br>Molecular weight: 443.50<br></br>Formula: C24H38N2O·2HCl<br></br>Solubility: DMSO (>25 mg/ml) Water (5 mg/ml)<br></br>Physical Properties: White or off-white solid<br></br>Purity: 99% by HPLC NMR (Conforms)
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.