bs-82970C
[Life Science]
AE 51310
DATASHEET
Formulation Off-white solid
Storage: -20°C
Product Information:
AE 51310 is a potent antagonist of the GPCR OPN4/melanopsin (Ki = 0.096 nM human OPN4).1 OPN4 regulates circadian rhythms, pupil functions, melatonin expression, cognition, and sleep. OPN4 has been found to bind G11 in lung cancer cells modulating PKC activation leading to activation of BRAF/MEK/ERK signaling pathways. AE 51310 decreased the growth and proliferation of both LG17 and LG55 lung cancer tumors in mouse xenograft models.
Description:
CAS Number: 433966-92-8<br></br>Chemical Name: 1-(2,5-Dichloro-4-methoxyphenyl)sulfonyl-3-methylpiperidine<br></br>Molecular weight: 338.24<br></br>Formula: C13H17Cl2NO3S<br></br>Solubility: DMSO (>25 mg/ml)<br></br>Physical Properties: White solid<br></br>Purity: 99% by HPLC NMR (Conforms)
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.