DATASHEET
Formulation
Beige solid
Storage:
-20°C
Product Information:
VU0134992 is a blocker of the inward rectifier potassium channel Kir4.1 (IC50 = 970 nM).1 It also inhibits Kir3.1/3.2, Kir3.1/3.4, and Kir4.2 with similar potency. VU0134992 induced diuresis, natriuresis, and kaliuresis in Sprague-Dawley rats suggesting therapeutic blood pressure lowering potential. It reduced polymyxin-induced nephrotoxicity in cell culture and mouse explant kidney tissue.2
Description:
CAS Number: 755002-90-5<br></br>Chemical Name: 2-(2-Bromo-4-propan-2-yl)phenoxy)-N-(2,2,6,6-tetramethlpiperidin-4-yl)acetamide<br></br>Molecular weight: 411.38<br></br>Formula: C20H31BrN2O2<br></br>Solubility: DMSO (>25 mg/ml)<br></br>Physical Properties: Off-white/tan solid<br></br>Purity: 98% by TLC NMR (Conforms)