bs-82966C
[Life Science]
Nitisinone
DATASHEET
Formulation Off-white solid
Storage: -20°C
Product Information:
Inhibitor of 4-Hydroxyphenylpyruvate dioxygenase (HPPD; IC50 = 40 nM1 and 173 nM2) and is in clinical use for the treatment of hereditary tyrosinemia type 13. CD13+ cancer stem cells (CSCs) are dependent on aerobic metabolism of tyrosine - Nitisinone inhibition of tyrosine metabolism results in lowered availability of acetyl-CoA and fumarate for use in the citric acid cycle causing these CSCs to enter cell cycle, decreasing self-renewal, and making them more susceptible to chemotherapy.4 Nitisinone is a potential treatment option for cancers that rely on tyrosine metabolism.
Description:
CAS Number: 104206-65-7<br></br>Chemical Name: 2-[2-Nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione<br></br>Molecular weight: 329.23<br></br>Formula: C14H10F3NO5<br></br>Solubility: DMSO (>10 mg/ml) Ethanol (10 mg/ml)<br></br>Physical Properties: Beige solid<br></br>Purity: >98% by TLC (NMR Conforms)
Size: 50 mg, 250 mg50 mg, 250 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.