bs-82959C
[Life Science]
Clodronate 2Na
DATASHEET
Formulation White solid
Storage: -20°C
Product Information:
Clodronate is a first generation non-nitrogenous bisphosphonate drug for the prevention and treatment of osteoporosis and skeletal fractures/hypercalcemia in patients with cancer. It strongly binds to hydroxyapatite and directly reduces osteoclast activity.1 Clodronate is metabolized in vitro to a cytotoxic ATP analog (AppCCl2p) which inhibits ADP/ATP translocase in the mitochondrial inner membrane leading to osteoclast apoptosis.2
Description:
CAS Number: 88416-50-6<br></br>Chemical Name: Dichloromethylenediphosphonic acid disodium tetrahydrate<br></br>Molecular weight: 360.92<br></br>Formula: CH2Cl2O6P2·2Na·4H2O<br></br>Solubility: Water (>10 mg/ml)<br></br>Physical Properties: White solid<br></br>Purity: 98%, NMR (Conforms)
Size: 10 mg, 50 mg10 mg, 50 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.