DATASHEET
Formulation
White solid
Storage:
-20°C
Product Information:
FPS-ZM1 is a high-affinity Receptor for Advanced Glycation End products (RAGE) inhibitor (IC50 = 0.6 μM). It is able to lower levels of Aβ via binding to the V domain of RAGE and can block multiple mechanisms of Aβ40- and Aβ42-induced cellular stress in RAGE-expressing brain endothelium, neurons and microglia in vitro and in vivo.1,2 Can cross the BBB. In a rat model of intracerebral hemorrhage, FPS-ZM1 was able to attenuate blood-brain barrier and white matter fiber damage.3 FPS-ZM1 inhibition of RAGE was able to ameliorate inflammatory damage after acute intracerebral hemorrhage via downstream blockade of high mobility box-1(HMGB1) signaling.4 FPS-ZM1 has also been shown to impair breast cancer cell invasion and metastasis.5
Description:
CAS Number: 945714-67-0<br></br>Chemical Name: 4-Chloro-N-cyclohexyl-N-(phenylmethyl)benzamide<br></br>Molecular weight: 327.85<br></br>Formula: C20H22ClNO<br></br>Solubility: DMSO (35 mg/ml) Ethanol (20 mg/ml)<br></br>Physical Properties: Off-White solid<br></br>Purity: 98% by HPLC, NMR (Conforms)