bs-82946C
[Life Science]
3PO
DATASHEET
Formulation Pale yellow oil
Storage: -20°C
Product Information:
3PO is an inhibitor of the metabolic enzyme 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3). PFKFB3 is constitutively expressed by neoplastic cells and is required for the high glycolytic rate (Warburg Effect) of these cells. 3PO inhibits PFKFB3 (IC50 = 1.4 – 24 µM for various cancer cell lines), suppresses glucose uptake, and lowers intracellular concentrations of Fru-2,6-BP, lactate, ATP, NAD+, and NADH.1 Inhibition of cancer cell metabolism via blocking the action of PFKFB3 has been studied in various models.2-4 Inhibition of PFKFB3 has been shown to induce autophagy as a survival mechanism in cancer cells.5 3PO has also been used to reduce pathological angiogenesis.6
Description:
CAS Number: 18550-98-6<br></br>Chemical Name: (2E)-3-(3-Pyridinyl)-1-(4-pyridinyl)-2-propen-1-one<br></br>Molecular weight: 210.23<br></br>Formula: C13H10N2O<br></br>Solubility: DMSO (15 mg/ml) Ethanol (5 mg/ml)<br></br>Physical Properties: Pale yellow solid<br></br>Purity: 99% by HPLC, NMR (Conforms)
Size: 10 mg, 50 mg10 mg, 50 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.