bs-82929C
[Life Science]
D,L-Buthionine Sulfoximine
DATASHEET
Formulation White solid
Storage: -20°C
Product Information:
D,L-Buthionine sulfoximine is an irreversible inhibitor of γ-glutamylcysteine ligase (GCL). GCL is the first enzyme of the cellular glutathione biosynthetic pathway. Dysregulation of glutathione homeostasis is involved in many diseases including cancer, diabetes, neurodegenerative disorders and HIV/AIDS.1 Most disease states involve decreased glutathione synthesis, however, in cancer, it is increased supporting cellular proliferation and protecting cancer cells. Pharmacological inhibition of GCL has been examined as a potential cancer treatment.2-4
Description:
CAS Number: 5072-26-4<br></br>Chemical Name: 2(S)-Amino-4-(S-butylsulfonimidoyl)butanoic acid<br></br>Molecular weight: 222.31<br></br>Formula: C8H18N2O3S<br></br>Solubility: Water (5 mg/ml)<br></br>Physical Properties: White solid<br></br>Purity: >98%, NMR (Conforms)
Size: 100 mg, 250 mg100 mg, 250 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.