bs-82928C
[Life Science]
Indoximod
DATASHEET
Formulation Off-white solid
Storage: -20°C
Product Information:
Indoximod is a modulator of indoleamine 2,3-dioxygenase (IDO) activity.1 IDO can be used by tumors to avoid elimination by the host immune response2,3, thus inhibition of IDO is an interesting cancer therapeutic option. Indoximod is not a direct inhibitor of IDO, but instead targets the IDO gene leading to downstream effects.3 IDO-mediated catabolism of tryptophan inhibits the immunoregulatory kinases mTOR and PKC5. This is relieved by Indoximod acting as a potent tryptophan mimetic restoring mTOR and PKC signaling.4
Description:
CAS Number: 110117-83-4<br></br>Chemical Name: 1-Methyl-D-tryptophan<br></br>Molecular weight: 218.25<br></br>Formula: C12H14N2O2<br></br>Solubility: DMSO (>25 mg/ml)<br></br>Physical Properties: White solid<br></br>Purity: >98%, NMR (Conforms)
Size: 50 mg, 250 mg50 mg, 250 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.