bs-82917C
[Life Science]
POB
DATASHEET
Formulation White solid
Storage: RT
Product Information:
Pyridoxal 5’-phosphate – dependent ornithine decarboxylase (ODC) is a key enzyme involved in polyamine synthesis and a potential cancer drug target. POB is a transition state-based, cell permeable pro-drug inhibitor of ODC. Intracellularly, POB is phosphorylated by pyridoxal kinase and the methyl ester hydrolyzed. This active inhibitor most likely binds apo-ODC resulting in greatly reduced ODC activity and inhibition of cellular proliferation. POB was able to inhibit proliferation in a wide variety of tumor cell lines: LN229 (IC50 = 50 µM), Jurkat, COS7, SW2 and both high and low-grade glioblastoma multiforme. More potent than DFMO.
Description:
CAS Number: 946135-39-3<br></br>Chemical Name: N-(4’-Pyridoxyl)-L-Ornithine(BOC)-Ome<br></br>Molecular weight: 397.47<br></br>Formula: C19H31N3O6<br></br>Solubility: Ethanol (25 mg/ml) DMSO (25 mg/ml) Water (2 mg/ml)<br></br>Physical Properties: White solid<br></br>Purity: 98% by HPLC, NMR (Confirms)
Size: 10 mg, 50 mg10 mg, 50 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.