bs-82910C
[Life Science]
7-Cl-O-Nec1
DATASHEET
Formulation White solid
Storage: -20°C
Product Information:
Necrostatin-1 analogue with superior potency (IC50 = 206nM vs 494nM), selectivity and metabolic stability in blocking RIP1.1,2 7-Cl-O-Nec-1 shows no off-target inhibition of indolamine-2,3-deoxygenase (IDO) in contrast to Necrostatin-1 (Nec-1).3,4 7-Cl-O-Nec-1 showed higher activity in inhibiting necroptosis in Jurkat cells than Necrostatin-1 (EC50 = 210 nM vs. EC50 = 490 nM), no non-specific cytotoxicity at high concentrations (100 µM) and reasonable pharmacokinetic characteristics when used in mice.2 7-Cl-O-Nec-1 is recommended for cellular and in vivo use over Necrostatin-1.5
Description:
CAS Number: 852391-15-2<br></br>Chemical Name: 5-((7-Chloro-1H-indol-3-yl)methyl)-3-methylimidazolidine-2,4-dione<br></br>Molecular weight: 277.71<br></br>Formula: C13H12ClN3O2<br></br>Solubility: DMSO (25 mg/ml)<br></br>Physical Properties: Yellow solid<br></br>Purity: 98% by TLC (5% methanol / methylene chloride; Rf = 0.55), NMR (Conforms)
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.