bs-82906C
[Life Science]
20(S)-Hydroxycholesterol
DATASHEET
Formulation White or pale yellow solid
Storage: -20°C
Product Information:
20-(S)-Hydroxycholesterol is an endogenous ligand for the LXR receptor.1 It has anti-adipogenic and pro-osteogenic effects in mesenchymal stem cells mediated via a non-LXR dependent pathway.2 The osteogenic effects of 20-(S)-hydroxycholesterol have been shown to be mediated by activation of hedgehog signaling and expression of genes associated with Notch signaling.3 Activation of Hedgehog is mediated via binding of 20(S)-hydroxycholesterol to Smoothened at a site distinct from the cyclopamine binding site.4,5
Description:
CAS Number: 516-72-3<br></br>Chemical Name: 5-Cholesten-3β, 20α-diol<br></br>Molecular weight: 402.66<br></br>Formula: C27H46O2<br></br>Solubility: DMSO or Ethanol<br></br>Physical Properties: White solid<br></br>Purity: 98% by TLC, NMR (Conforms)
Size: 1 mg, 5 mg 5 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.