bs-82890C
[Life Science]
Salubrinal
DATASHEET
Formulation White solid
Storage: -20°C
Product Information:
Endoplasmic reticulum (ER) stress inhibitor. Salubrinal is a selective inhibitor of cellular complexes that dephosphorylate eukaryotic initiation factor 2 subunit alpha (eIF2α).1 It has been found to interact with the anti-apoptotic protein Bcl-2 offering protection from the apoptotic and autophagic effects that result from loss of Bcl-2 function.2 Salubrinal blocked NFATc1 expression and osteoclast differentiation by RANKL via phosphorylation of eLF2α resulting in a decrease of global protein synthesis. It efficiently blocked osteoporosis in a mouse model treated with RANKL.3
Description:
CAS Number: 405060-95-9<br></br>Chemical Name: 3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide<br></br>Molecular weight: 479.81<br></br>Formula: C21 H17 Cl3 N4 O S<br></br>Solubility: DMSO (25 mg/ml)<br></br>Physical Properties: Beige solid<br></br>Purity: 98% by TLC [1% methanol in methylene chloride Rf = 0.35], NMR (Conforms)
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.