bs-82880C
[Life Science]
PF-06840003
DATASHEET
Formulation White solid
Storage: -20°C
Product Information:
PF-06840003 (198474-05-4) is a potent (IC50 = 150 and 410 nM via two methods) and selective inhibitor of Indoleamine-2,3-dioxygenase (IDO1).1 In mice with syngeneic tumor grafts, it reduced intratumoral kynurenine levels by over 80%, inhibited tumor growth as monotherapy, and increased the efficacy of anti-PD-L1 therapy.2 PF-06840003 treatment combined with GM-CSF-secreting allogenic pancreatic tumor cell vaccine (GVAX) resulted in increased antitumor efficacy in a murine model of pancreatic ductal adenocarcinoma.3
Description:
CAS Number: 198474-05-4<br></br>Chemical Name: 3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione<br></br>Molecular weight: 232.21<br></br>Formula: C12H9FN2O2<br></br>Solubility: DMSO (>25 mg/ml)<br></br>Physical Properties: White solid<br></br>Purity: 98% by TLC NMR (Conforms)
Size: 10 mg, 50 mg10 mg, 50 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.