bs-82868C
[Life Science]
SBI-553
DATASHEET
Formulation Pale yellow solid
Storage: -20°C
Product Information:
SBI-553 is a potent, brain penetrant, and orally bioavailable allosteric modulator of neurotensin receptor 1 (NTSR1; EC50 = 340 nM)).1 It acts as a ß-Arrestin-biased agonist and selectively antagonizes G protein signaling conferring profound ß-Arrestin bias towards the endogenous ligand.2,3 SBI-553 displayed efficacy in mouse models of psychostimulant abuse without the characteristic undesirable side effects of unbiased NTSR1 agonism. This functionally selective modulation of NTSR1 may be a new therapeutic approach to treating psychostimulant abuse and other chemical and behavioral addictions.
Description:
CAS Number: 1849603-72-0<br></br>Chemical Name: 2-[[2-(1-Fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl)quinazolin-6-yl]methylamino]ethanol<br></br>Molecular weight: 450.56<br></br>Formula: C26H31FN4O2<br></br>Solubility: DMSO (12 mg/ml)<br></br>Physical Properties: Pale yellow solid<br></br>Purity: >98% by HPLC NMR (conforms)
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.