bs-82864C

DATASHEET

Formulation Yellow solid

Storage: -20°C

Product Information:

Dual inhibitor of the Rho GTPases Rac (IC50 = 103 nM) and Cdc42 (IC50 = 78 nM).1 It inhibits breast cancer cell migration, viability, and mammosphere formation. MBQ-167 induced polarity loss resulting in 95% cell rounding and detachment from the substratum in metastatic MDA-MB-231 cells and was active in GFP-HER2-BM, MDA-MB-468, and Hs578t breast cancer cells as well as Mia-PaCa-2 pancreatic cancer cells, SKOV3 ovarian cancer cells, AGS and NCI-N87 gastric cancer cells, and SH-SY5Y neuroblastoma cells. Non-cancerous mammary epithelial MCF10A and epithelial breast cancer MCF-7 cells were resistant to MBQ-167. MBQ-167 inhibited viability and induced apoptosis in gefitinib and lapatinib resistant SKBR3 breast cancer cells.2 MBQ-167 inhibited triple negative breast cancer tumor growth and lung metastasis in a mouse model.3 Active in vivo.

Description:

CAS Number: 2097938-73-1 Chemical Name: 1-(9-Ethyl-9H-carbazol-3-yl)-5-phenyl-1H-1,2,3-triazole; 9-Ethyl-3-(5-phenylcarbazol-1-yl)carbazole Molecular weight: 338.41 Formula: C22H18N4 Solubility: DMSO (25 mg/ml) Physical Properties: Off-white solid Purity: >98% by HPLC NMR (Conforms)