bs-82853C
[Life Science]
Ki8751
DATASHEET
Formulation Off white or beige solid
Storage: -20°C
Product Information:
Very potent (IC50 = 0.9 nM) inhibitor of vascular endothelial growth factor receptor 2 (VEGFR-2).1 It also inhibited PDGFRα (IC50 = 67 nM), c-Kit (IC50 = 40 nM), and FGFR2 (IC50 = 170 nM). Ki8751 completely suppressed HUVEC growth at 1 nM. Ki8751 completely inhibited tumor growth in LC-6 human tumor xenografts @ 5mg/kg. Ki8751 displayed anti-influenza A and B activity via disruption of virus entry in a PDGFRß/GM3-dependent manner.2
Description:
CAS Number: 228559-41-9<br></br>Chemical Name: N-(2,4-Difluorophenyl)-N’-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl]urea<br></br>Molecular weight: 469.42<br></br>Formula: C24H18F3N3O4<br></br>Solubility: DMSO (15 mg/ml)<br></br>Physical Properties: White solid<br></br>Purity: >98% by HPLC NMR (Conforms)
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.