bs-82851C
[Life Science]
Icilin
DATASHEET
Formulation Off-white solid
Storage: -20°C
Product Information:
Icilin is an agonist of cold-sensitive TRP channels with 2.5-fold greater efficacy and 200-fold greater potency than menthol (EC50 = 0.36 µM for CRM1, rat orthologue of TRPM8).1 Agonist at TRPM8 (EC50 = 0.2 µM)2 and ANKTM1(TRPA1)3. Agonist effects require Ca2+ and are pH dependent.2,4 Icilin induced G1 arrest in PC-3 prostate cancer cells without cell death.5
Description:
CAS Number: 36945-98-9<br></br>Chemical Name: 3,6-Dihydro-1-(2-hydroxyphenyl)-4-(3-nitrophenyl)-1H-pyrimidin-2-one<br></br>Molecular weight: 311.29<br></br>Formula: C16H13N3O4<br></br>Solubility: DMSO (25 mg/ml)<br></br>Physical Properties: Yellow solid<br></br>Purity: >98% by TLC [5% methanol in methylene chloride; Rf = 0.40]
Size: 10 mg, 50 mg10 mg, 50 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.