bs-82847C

DATASHEET

Formulation White solid

Storage: -20°C

Product Information:

Potent pan-Class I PI3-kinase inhibitor (IC50’s: p110α = 52 nM, p110ß = 166 nM, p110δ = 116 nM. P110g = 262 nM).1,2 It inhibited microtubule dynamics at in vitro concentrations >1µM and doses above 50mg/kg in mice.3 Buparlisib lead to a precipitous drop in DNA synthesis in a mouse model of BRCA1-linked triple-negative breast cancer with less affect in normal tissue.4

Description:

CAS Number: 944396-07-0 Chemical Name: 5-(2,6-Dimorpholin-4-ylpyrimidin-4-yl)-4-(trifluoromethyl)pyridine-2-amine Molecular weight: 410.39 Formula: C18H21F3N6O2 Solubility: DMSO (15 mg/ml) Physical Properties: White solid Purity: 99% by HPLC, NMR (Conforms)

Size: 5 mg, 25 mg5 mg, 25 mg

Applications: Life Science()

For research use only. Not intended for diagnostic or therapeutic use.