bs-82842C
[Life Science]
XMU-MP-1
DATASHEET
Formulation White solid
Storage: -20°C
Product Information:
XMU-MP-1 is a potent, reversible, and selective inhibitor of the HIPPO pathway kinases MST1 and MST2 (IC50s = 71 nM and 38 nM respectively).1 It promoted liver repair/regeneration in mice and attenuated acetaminophen-induced liver injury. In a subarachnoid hemorrhage mouse model, XMU-MP-1 alleviated neurological deficits, brain edema, neuroinflammation, and white matter injury.2 XMU-MP-1 was also cardioprotective in mice with transverse aortic constriction3 and against ischemia/reperfusion injury4.
Description:
CAS Number: 2061980-01-4<br></br>Chemical Name: 4-[(6,10-Dihydro-5,10-dimethyl-6-oxo-5H-pyrimido[5,4-b]thieno[3,2-e]diazepin-2-yl)amino]benzenesulfonamide<br></br>Molecular weight: 416.47<br></br>Formula: C17H16N6O3S2<br></br>Solubility: DMSO (15 mg/ml)<br></br>Physical Properties: Yellow solid<br></br>Purity: >98% by HPLC, NMR (Conforms)
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.