bs-82833C
[Life Science]
Quinacrine hydrochloride
DATASHEET
Formulation White solid
Storage: -20°C
Product Information:
Quinacrine is an antiprotozoan drug used for malaria and giardiasis and has recently been investigated in treating lupus, as an anticancer agent, inflammation, and as a female sterilization agent.1 It has been found to have synergistic effects with vorinostat in the treatment of T-cell acute lymphoblastic leukemia via mitophagy blockage and an increase in ROS.2 Quinacrine displayed antitumor effects an intestinal cancer mouse model and HCT116 p53-/- xenografts via reduction in Chk1/2 expression and cell death induction in the G2-M phase.3 It promotes autophagic cell death in ovarian cancer cells via downregulation of p62/SQSTM1.4 Quinacrine is also an inhibitor of phospholipase A2.5
Description:
CAS Number: 69-05-6<br></br>Chemical Name: 6-Chloro-9-(4-diethylamino-1-methylbutyl)amino-2-methoxyacridine dihydrochloride <br></br>Molecular weight: 472.88<br></br>Formula: C23H30ClN3O·2HCl<br></br>Solubility: Water (>25 mg/ml) DMSO (>10 10 mg/ml)<br></br>Physical Properties: Yellow solid<br></br>Purity: 98% by HPLC, NMR (Confirms)
Size: 20 mg, 100 mg20 mg, 100 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.