bs-82822C
[Life Science]
Siramesine
DATASHEET
Formulation Off-white solid
Storage: -20°C
Product Information:
Siramesine (Lu 28-179) is a 2 selective agonist (IC50’s: 1 = 17nM, 2 = 0.2nM).1 It produced non-sedating potent and long-last anxiolytic effects in rodents.2 Siramesine induced caspase-independent programmed cell death in various cancer cell lines via increased levels of ROS and lysosomal leakage.3,4,5 Mitochondrial destabilization via loss of membrane potential and increased ROS has also been offered as a mechanism of action for the triggering of cell death by Siramesine.6
Description:
CAS Number: 147817-50-3<br></br>Chemical Name: 1’-[4-[1-(4-Fluorophenyl)indol-3-yl]butyl]spiro[1H-2-benzofuran-3,4’-piperidine; <br></br>Molecular weight: 454.59<br></br>Formula: C30H31FN2O<br></br>Solubility: DMSO (>25 mg/ml)<br></br>Physical Properties: White solid<br></br>Purity: 98% by HPLC NMR (Conforms)
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.