bs-82816C
[Life Science]
GSK2830371
DATASHEET
Formulation White solid
Storage: -20°C
Product Information:
Potent allosteric inhibitor of WIP1 phosphatase (IC50 = 6 nM), a negative regulator of the DNA damage response.1 It displayed no inhibition of 21 other phosphatases. Active in xenograft model DoHH2 B-cell lymphoma. GSK2830371 in combination with MDM2 inhibitors has been shown to be efficacious in the treatment of various cancers including liver adenocarcinoma2, acute myeloid leukemia3, and breast4. It enhances phosphorylation of the tumor suppressor p53 leading to activation.5,6
Description:
CAS Number: 1404456-53-6<br></br>Chemical Name: 5-[[(5-Chloro-2-methylpyridin-3-yl)amino]methyl]-N-[(2S)-3-cyclopentyl-1-(cyclopropylamino)-1-oxopropan-2-yl]thiophene-2-carboxamide<br></br>Molecular weight: 461.02<br></br>Formula: C23H29ClN4O2S<br></br>Solubility: DMSO (>25 mg/ml) <br></br>Physical Properties: Tan solid<br></br>Purity: 97% by HPLC NMR (Conforms)
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.