bs-82815C
[Life Science]
PRIMA-1MET
DATASHEET
Formulation Pale yellow solid
Storage: -20°C
Product Information:
PRIMA-1MET reactivates mutant p53, an important tumor suppressor gene, in cancer cells.1 It induces p53-dependent mitochondrial apoptosis via activation of caspase-2.2 PRIMA-1MET showed significant antitumor activity in multiple myeloma via activation of p733 and had previously been shown to target p53 family members p63 and p734. Tumor cell death by PRIMA-1MET has been also shown to be caused by glutathione depletion and induced ROS production in a p53 independent manner.5-7 PRIMA-1MET probably induces tumor cell death by both reactivating mutant p53 and inhibiting cellular thiol-dependent redox systems.8
Description:
CAS Number: 5291-32-7<br></br>Chemical Name: 2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one<br></br>Molecular weight: 199.25<br></br>Formula: C10H17NO3<br></br>Solubility: DMSO (20 mg/ml)<br></br>Physical Properties: White solid<br></br>Purity: 95%, NMR (Conforms)
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.