bs-82805C
[Life Science]
P22077
DATASHEET
Formulation Off-white solid
Storage: -20°C
Product Information:
P22077 is a selective (tested against 23 other DUBs) inhibitor of USP7 (IC50 = 8 µM) and the closely related USP47.1,2 It destabilizes claspin, a scaffolding protein involved in regulating Chk1 kinase, a DNA damage response enzyme.2 P22077 inhibits neuroblastoma growth via induction of p53-mediated apoptosis.3 N-Myc was destabilized by P22077 inhibition of USP7 in human neuroblastoma cells.4 It was able to stabilize p53 levels in conjunction with an Mdm2 inhibitor (Nutlin-3, Cat# 10-1350) in HCT116 colorectal carcinoma cells.5
Description:
CAS Number: 1247819-59-5<br></br>Chemical Name: 1-(5-((2,4-Difluorophenyl)thio)-4-nitrothiophen-2-yl)ethanone<br></br>Molecular weight: 315.32<br></br>Formula: C12H7F2NO3S2 <br></br>Solubility: DMSO (25 mg/ml)<br></br>Physical Properties: Off-white solid<br></br>Purity: 98% by HPLC, NMR (Conforms)
Size: 10 mg, 50 mg10 mg, 50 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.