bs-82804C
[Life Science]
Alisertib
DATASHEET
Formulation Off-white solid
Storage: -20°C
Product Information:
Alisertib (MLN8237) is a highly selective and potent (IC50 = 1 nM) cell permeable inhibitor of Aurora A with off-target binding at GABAA (IC50 = 490 nM).1 It disrupts the Aurora A-Myc complex leading to Myc degradation2 in Myc amplified neuroblastomas3 and p53-mutant human hepatocellular carcinoma cell4. Alisertib has been found to induce apoptosis and autophagy in breast cancer5 and melanoma6 cells via suppression of activation of the p38 MAPK pathway.
Description:
CAS Number: 1028486-01-2<br></br>Chemical Name: 4-{[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino}-2-methoxybenzoic acid<br></br>Molecular weight: 518.92<br></br>Formula: C27H20ClFN4O4 <br></br>Solubility: DMSO (5 mg/ml)<br></br>Physical Properties: Off-white solid<br></br>Purity: 98% by HPLC, NMR (Conforms)
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.