bs-82801C
[Life Science]
BI 2536
DATASHEET
Formulation Tan solid
Storage: -20°C
Product Information:
BI 2536 was originally reported as a potent (IC50’s Plk1 = 0.83nM, Plk2 = 3.5nM and Plk3 = 9.0nM) and selective2 Polo-like kinase inhibitor (IC50’s Plk1 = 0.83nM, Plk2 = 3.5nM and Plk3 = 9.0nM) that caused mitotic arrest and apoptosis induction in various human cancer cell lines.1 It was later found to be a potent inhibitor (IC50 = 100nM) of BET family member BRD4 and able to potently suppress c-Myc expression in MM.1S multiple myeloma cells.3 BI 2536 destabilizes N-Myc by inhibiting the deactivation of the ubiquitin E3 ligase Fbw7 by Plk1.4
Description:
CAS Number: 755038-02-9<br></br>Chemical Name: 4-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide<br></br>Molecular weight: 521.67<br></br>Formula: C28H39N7O3 <br></br>Solubility: DMSO (20 mg/ml) Ethanol (>25 mg/ml)<br></br>Physical Properties: Off-white solid<br></br>Purity: 97% by HPLC, NMR (conforms)
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.