bs-82799C
[Life Science]
UNC6934
DATASHEET
Formulation White or off-white solid
Storage: -20°C
Product Information:
Potent (IC50 = 104 nM) and selective inhibitor of protein lysine methyltransferase nuclear receptor-binding SET domain-containing 2 (NSD2). It potently binds to the PWWP1 domain antagonizing interaction with nucleosomal H3K36me2. UNC6934 is selective against 14 other human PWWP domains and 33 methyltransferases. Active in a nanoBRET PPI assay in U2OS cells (IC50 = 1.23 µM).
Description:
CAS Number: 2561494-77-5<br></br>Chemical Name: N-Cyclopropyl-3-oxo-N-(4-pyrimidin-4-ylcarbamoyl)benzyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carboxamide<br></br>Molecular weight: 443.46<br></br>Formula: C24H21N5O4<br></br>Solubility: DMSO (>25 mg/ml)<br></br>Physical Properties: Pale yellow solid<br></br>Purity: 98% by HPLC NMR (Conforms)
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.