bs-82775C
[Life Science]
iJMJD6
DATASHEET
Formulation Off-white solid
Storage: -20°C
Product Information:
Inhibitor of the arginine demethylase JMJD6 (IC50 = 220 nM) with selectivity over other JmjC domain-containing proteins.1 Exhibited antiproliferative effects in HeLa (EC50 = 1.49 µM), SMCC7721 (EC50 = 9.37 µM), and MCF7 (EC50 = 9.53 µM) cells.2 Displayed no cytotoxicity towards normal cervical, liver, and breast epithelial cells. iJMJD6 significantly suppressed tumor growth in a HeLa, SMCC7721, MCF7, MDA-MB-231, U87, and HCT116 mouse xenograft models.2
Description:
CAS Number: 899548-78-8<br></br>Chemical Name: 3-(3H-Imidazo[4,5-c]pyridine-2-yl)-6-methylchromen-2-one<br></br>Molecular weight: 277.28<br></br>Formula: C16H11N3O2<br></br>Solubility: DMSO (>12 mg/ml with warming)<br></br>Physical Properties: Yellow solid<br></br>Purity: >98% HPLC, NMR (Conforms)
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.