bs-82764C
[Life Science]
PTC-209
DATASHEET
Formulation Off-white solid
Storage: -20°C
Product Information:
An inhibitor of BMI-1 (IC50 = 500 nM), part of the polycomb repressive complex 1 (PCR1).1 It inhibited endogenous BMI-1 expression in human colorectal HCT116 and human fibrosarcoma HT1080 tumor cells resulting in reduced tumor volume as well as reduced cancer initiating cell (CIC) number. PTC-209 displayed potent in vivo antitumor effects in several cancer models including breast2, head and neck3, glioblastoma4, prostate5, colon5, and rhabdomyosarcoma6. It also promoted chemically-induced direct cardiac reprogramming of cardiac fibroblasts into cardiac myocytes.7,8
Description:
CAS Number: 315704-66-6<br></br>Chemical Name: N-(2,6-Dibromo-4-methoxyphenyl)-4-(2-methylimidazol[1,2-a]pyrimidin-3-yl)-2-thiazolamine<br></br>Molecular weight: 495.19<br></br>Formula: C17H13Br2N5OS<br></br>Solubility: DMSO (>25 mg/ml)<br></br>Physical Properties: Yellow solid<br></br>Purity: 98% by HPLC , NMR (Conforms)
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.