bs-82760C
[Life Science]
A-196
DATASHEET
Formulation Off-white or beige solid
Storage: -20°C
Product Information:
A-196 (1982372-88-2) is a potent and selective (over 29 other methyltransferases) inhibitor of the protein lysine methyltransferases SUV420H1(IC50 = 25 nM) and SUV420H2 (IC50 = 144 nM). It substantially inhibited non-homologous end-joining (NHEJ)-directed DNA repair but not homology-directed repair(HDR) in cells treated with ionizing radiation. A-196 is active in cells and displayed no toxicity in several cell lines.
Description:
CAS Number: 1982372-88-2<br></br>Chemical Name: Cyclopentyl-(6,7-dichloro-4-pyridin-4-yl-phthalazin-1-yl)-amine<br></br>Molecular weight: 359.25<br></br>Formula: C18H16Cl2N4<br></br>Solubility: DMSO (5 mg/ml)<br></br>Physical Properties: White solid<br></br>Purity: 98% by TLC NMR (Conforms)
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.