bs-82754C
[Life Science]
Selinexor
DATASHEET
Formulation Pale yellow solid
Storage: -20°C
Product Information:
Selinexor is a potent inhibitor of the nuclear export receptor, chromosome region maintenance 1 (CRM1; Exportin-1 (XPO1)). It exhibited potent growth suppression in various T-cell acute lymphoblastic leukemia (T-ALL) cells (IC50’s = 34-203 nM)1 and pancreatic cancer cells (IC50 ~ 150 nM)2. Selinexor is being investigated as a possible chemotherapeutic in treating multiple types of cancer.3-8 Currently in clinical trials.
Description:
CAS Number: 1393477-72-9<br></br>Chemical Name: (Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]-N’-pyrazin-2-ylprop-2-enehydrazide; <br></br>Molecular weight: 443.31<br></br>Formula: C17H11F6N7O<br></br>Solubility: DMSO (>25 mg/ml) Ethanol (>25 mg/ml)<br></br>Physical Properties: Off-white solid<br></br>Purity: 98% by TLC NMR (Conforms)
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.