bs-82752C
[Life Science]
SR0987
DATASHEET
Formulation White or pale yellow solid
Storage: -20°C
Product Information:
RORγt is a T cell specific isoform of ROR that is a key transcription factor for initiating the differentiation of Th17 and Tc17 cells. SR0987 (303126-97-8) is a RORγt agonist that drives proliferation of Th17 cells and decrease levels of the immune checkpoint protein PD-1. In a Ga14 UAS-Luc cotransfection system, SR0987 induced reporter gene expression (EC50 = 800nM). Treatment of human Jurkat T cells with SR0987 resulted in decreased cell surface PD-1 expression. RORγt agonists may synergize with current anti-PD-1 therapy and represent a new potential class of cancer immunotherapeutic.
Description:
CAS Number: 303126-97-8<br></br>Chemical Name: 2-Chloro-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]benzamide<br></br>Molecular weight: 397.70<br></br>Formula: C16H10F6NO2<br></br>Solubility: DMSO (>25 mg/ml), Ethanol (>25 mg/ml)<br></br>Physical Properties: White solid<br></br>Purity: 98% by HPLC NMR (Conforms)
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.