bs-82748C
[Life Science]
Pridopidine
DATASHEET
Formulation White solid
Storage: RT
Product Information:
Pridopidine is being studied as a potential treatment for Huntington’s disease, Parkinson’s disease, and schizophrenia based on its locomotor stabilizing and antipsychotic-like effects.1,2 It was, unusually, able to reverse both hypo- and hyperdopaminergia depending on local dopamine concentrations without inducing catalepsy. This was originally attributed to functional dopamine D2 antagonism with fast on/off kinetics (“dopamine stabilizer”).3 More recent studies have attributed pridopidine's effects to its being a more potent sigma-1 ligand than a D2 ligand.4,5 Displays neuroprotective/restorative effects6,7 and ameliorates central features of amyotrophic lateral sclerosis pathology8 in a sigma-1-mediated manner
Description:
CAS Number: 346688-38-8<br></br>Chemical Name: 4-(3-(Methylsulfonyl)phenyl)-1-propylpiperidine<br></br>Molecular weight: 281.41<br></br>Formula: C15H23NO2S<br></br>Solubility: DMSO (>25 mg/mL)<br></br>Physical Properties: Off-white solid<br></br>Purity: 98% by TLC NMR (Conforms)
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.