DATASHEET
Formulation
White solid
Storage:
-20°C
Product Information:
Preferential activator of the ER stress sensing protein ATF6.1 It was able to selectively reduce secretion and extracellular aggregation of destabilized amyloidogenic variants of TTR and LC proteins. AA147-dependent ATF6 activation proceeds via metabolic activation to a reactive electrophile that selectively modifies ER proteins including multiple protein disulfide isomerases.2 AA147 suppressed pluripotency and promoted human stem cell differentiation toward a mesodermal lineage via ER expansion.3 It protected the heart against ischemia/reperfusion (I/R) injury in a mouse model of acute myocardial infarction in an ATF6-dependent manner.4 Brain, kidney, and liver tissue was also protected from I/R damage and impaired proteostasis. AA147 reduced infection of multiple strains of dengue and Zika viruses in an ATF6-independent manner.5 Protects against glutamate-induced cell death is a neuronal-derived cell culture model.6 See companion inhibitor 10-3974.
Description:
CAS Number: 393121-74-9<br></br>Chemical Name: N-(2-Hydroxy-5-methylphenyl)-3-phenylpropanamide<br></br>Molecular weight: 255.32<br></br>Formula: C16H17NO2<br></br>Solubility: DMSO (>25 mg/ml); ethanol (>25 mg/mL)<br></br>Physical Properties: Beige to pale orange solid<br></br>Purity: 98% by HPLC , NMR (Conforms)