bs-82740C
[Life Science]
Brequinar sodium
DATASHEET
Formulation White solid
Storage: -20°C
Product Information:
Brequinar sodium is an inhibitor of dihydroorotate dehydrogenase (DHODH)1,2 with IC50’s between 0.2 and 5.8 µM in various cell lines3 and 20 nM in isolated enzyme4. It reduced leukemic cell burden, decreased levels of leukemia-initiating cells, and improved survival in human and mouse models of acute myeloid leukemia.4 Brequinar displayed broad antiviral activity against flaviviruses, positive-strand RNA alphaviruses, negative-strand RNA rhabdoviruses, Influenza A and B viruses, and HIV.5,6,7
Description:
CAS Number: 96201-88-6<br></br>Chemical Name: 6-Fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquinoline-4-carboxylic acid sodium salt<br></br>Molecular weight: 397.35<br></br>Formula: C23H14F2NO2·Na<br></br>Solubility: DMSO (>25 mg/ml) Water (15 mg/ml) <br></br>Physical Properties: White to off-white solid<br></br>Purity: 99% by HPLC NMR Conforms
Size: 10 mg, 50 mg10 mg, 50 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.