bs-82737C
[Life Science]
ML382
DATASHEET
Formulation White to off-white solid
Storage: -20°C
Product Information:
ML382 is a potent (EC50 = 190 nM in the presence of the endogenous peptide MRGX1 agonist BAM8-22) and selective positive allosteric modulator of the Mas-related G protein-coupled receptor X1 (MRGX1 or MRGPRX1), a receptor whose expression is limited to subsets of small-diameter sensory neurons in dorsal root ganglia and trigeminal neurons.1 ML382 significantly enhanced the antihyperalgesic effects of exogenously added BAM8-22 and in mouse models of persistent pain without exogenous BAM8-22, suggesting enhanced pain inhibition from a sufficient supply of endogenous MRGPRX1 ligands and a potential new pain therapeutic.2
Description:
CAS Number: 1646499-97-9<br></br>Chemical Name: 2-(Cyclopropanesulfonylamimo)-N-(2-ethoxyphenyl)benzamide<br></br>Molecular weight: 360.43<br></br>Formula: C18H20N2O4S<br></br>Solubility: DMSO (>25 mg/ml); ethanol (5 mg/mL with warming)<br></br>Physical Properties: White solid<br></br>Purity: 99% by HPLC NMR (Conforms)
Size: 10 mg, 50 mg10 mg, 50 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.