bs-82735C
[Life Science]
E7820
DATASHEET
Formulation White solid
Storage: -20°C
Product Information:
E7820 is an angiogenesis inhibitor that suppresses expression of integrins α2, α3, α5, and ß1.1 Broad-spectrum antitumor and antiangiogenic effects are mainly mediated via integrin α2 suppression.2 E7820 has been identified as a molecular glue that induces proteasomal degradation of the U2AF-related splicing factor CAPERα (RBM39) via CRL4DCAF15 mediated ubiquitination in human cancer cell lines.3,4 E7820 has also been shown to induce degradation of the aryl hydrocarbon receptor nuclear translator (ARNT), a protein essential in maintaining cellular homeostasis in response to environmental stress.5
Description:
CAS Number: 289483-69-8<br></br>Chemical Name: N-(3-Cyano-4-methyl-1H-indol-7-yl)-3-cyanobenzenesulfonamide<br></br>Molecular weight: 336.37<br></br>Formula: C17H12N4O2S<br></br>Solubility: DMSO (>25 mg/ml)<br></br>Physical Properties: White solid<br></br>Purity: 98% by HPLC , NMR (Conforms)
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.